中国全科医学2011，Vol.14Issue(25)：2894-2896,3.
奥卡西平治疗新诊断的部分性癫痫的疗效及其对脑电活动的影响
Curative Effect of Oxcarbazepine on Newly Diagnosed Partial Epilepsy and Its Impact on Brain Electrical Activity
摘要
Abstract
Objective To investigate the curative effect of oxcarbazepine ( OXC ) in newly diagnosed partial epilepsy patients and its impact on brain electrical activity. Methods A self - controlled, open - lable study was carried out among fifty adults with newly diagnosed partial epilepsy receiving OXC monotherapy. Curative effect and impact on brain electrical activity among the subjects were observed after one month, six months, and twelve months of therapy. Results After one month of OXC therapy, the outcome turned out to be complete effective in 29 cases ( 58.0％ ); ≥75％ seizure frequency reduction was seen in 9 cases ( 18.0％ ), ≥50％ seizure frequency reduction was seen in 8 cases ( 16.0％ ), and ≤49％ seizure frequency reduction was seen in 4 cases ( 8.0％ ). Total effective rate was 92.0％. No statistical differences in efficacy were observed among 1,6, and 12 months of OXC treatment ( H = 0.559 , P＞0.05 ). After six months of OXC therapy, IEA either vanished or showed ≥50％ decrease in 26 cases ( 52％ ) and the numher was 29 ( 58％ ) for twelve months of treatment. As for brain electrical activity mapping, significant increase of the relative power of 0 band was ohserved ( P＜0.05 ) while no significant differences of the relative power of α, β and δ bands were noted after six month therapy ( P＞0.05 ). Conclusion OXC monotherapy is effective for adults with newly diagnosed partial epilepsy. OXC monotherapy might diminish or even vanish IEA and shows little impact on the hackground of EEG activity.关键词
癫痫,部分性/奥卡西平/脑电图Key words
Epilepsies, partial/ Oxcarbazepine/ Electroencephalogram分类
医药卫生引用本文复制引用
李哲,杨春清,杨环玲,刘倩薇,李文玲..奥卡西平治疗新诊断的部分性癫痫的疗效及其对脑电活动的影响[J].中国全科医学,2011,14(25):2894-2896,3.基金项目
河北省卫生厅基金项目(20100003) （20100003）
