首页|期刊导航|中国神经再生研究（英文版）|Basic fibroblast growth factor improves learning and memory functions in chronic stress mice
中国神经再生研究（英文版）2011，Vol.6Issue(19)：1473-1477,5.DOI:10.3969/j.issn.1673-5374.2011.19.006
Basic fibroblast growth factor improves learning and memory functions in chronic stress mice
Basic fibroblast growth factor improves learning and memory functions in chronic stress mice
摘要
Abstract
Four weeks of uncertain stress was used to establish an animal model of chronic stress.Basic fibroblast growth factor was injected daily for 15 days following stress induction.Cell morphology in the hippocampal CA3 region of chronic stress mice revealed cell damage.Nitric oxide content and calcium concentration were significantly increased in the hippocampus,and learning and memory functions were significantly decreased.After basic fibroblast growth factor intervention,Ca2+ overload was decreased and neuronal damage was relieved in hippocampal neurons,which improved learning and memory functions in chronic stress mice.Latency was prolonged and the number of errors was decreased in a passive avoidance test.关键词
basic fibroblast growth factor/chronic stress/step-down test/passive avoidance test/learning and memory/nitric oxide/neural regenerationKey words
basic fibroblast growth factor/chronic stress/step-down test/passive avoidance test/learning and memory/nitric oxide/neural regeneration引用本文复制引用
Xian Qu,Chunying Li,Hongchang Liu,Chang Su..Basic fibroblast growth factor improves learning and memory functions in chronic stress mice[J].中国神经再生研究（英文版）,2011,6(19):1473-1477,5.基金项目
the "E leventh Five-Year" Scientific and Technological Research Projects of the Education Department of Jilin Province,No.[2008]137 （）
