中国免疫学杂志2011，Vol.27Issue(9)：809-813,5.DOI:10.3969/j.issn.1000-484X.2011.09.011
重组GnRH主动免疫对公猪体重及生长激素和IGF-I的影响
Effects of body weight,growth hormone and IGF-I of active immunization against recombinant GnRH in boars
摘要
Abstract
Objective:To explore effects of body wright,growth home one and insulin-like growth factor-Ⅰ of active immunization against recom viant gonadotrpin relesing gome one(MBP-GnRH-6)in boars.Methods:Seven boars at 9 weeks were actibely immunized againsy MBP-GnRH-6,and the booster immunization was adm inistered at 17 weeks.The body weights were mesuted at ld before immunization and slaughter,respectively.The concentrations of PGH,IGF-I and testosterone(T)in serum were detem ined by enzyme-linked immunosorbent assay and radioimmunoassay,respectively.Potential correlation between testosterone and IGF-I in serum was analyzed with Pearson correlation.Results:Active immunization against MBP-GnRH-6 and reduced serum cincentration of tetodterone(p＜0.05)compared to positive control,and incresed the body weight compared to negative control(p＜0.05),but did not affect the level of PGH in serum of boars(p＜0.05).However,IGF-I concentration of serum in MBP-GnRH-6 immunized boars was significantly lower than that of the control group at 17-21weeks of age(p＜0.05),and markedly higher than that of the negative control animals at 21-25 weeks of age(p＜0.050.Serum testoterone was positively comelted with IGF-I .Conlusion:Active immunization against MBP-GnRH-6incresed body weight (p＜0.05)and the level of IGF-I(P＜0.05),and its pathway may control serum IGF-I by serum testosterone in boars.关键词
重组GnRH/公猪/体重/生长激素/IGF-IKey words
Recom binant gonadotropin relesaing homone/Boar/Body weight/Growth homone/IGF-I分类
农业科技引用本文复制引用
方富贵,张运海,刘亚,苏时萍,蒲勇,李运生,陶勇,章孝荣..重组GnRH主动免疫对公猪体重及生长激素和IGF-I的影响[J].中国免疫学杂志,2011,27(9):809-813,5.基金项目
本文为安徽省教育厅自然科研重点项目(KJ2011A117) （KJ2011A117）
