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Reduced glutathione alleviates the toxic effect of 6-hydroxydopamine on bone marrow stromal cells

Henghui Wang Weifeng Luo Xiaoxia Wang Xiaoling Qin Shiyao Bao

中国神经再生研究（英文版）2011，Vol.6Issue(22)：1691-1695,5.

中国神经再生研究（英文版）2011，Vol.6Issue(22)：1691-1695,5.DOI:10.3969/j.issn.1673-5374.2011.22.002

Reduced glutathione alleviates the toxic effect of 6-hydroxydopamine on bone marrow stromal cells

Henghui Wang ¹Weifeng Luo ¹Xiaoxia Wang ²Xiaoling Qin ¹Shiyao Bao¹

作者信息

1. Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu Province, China
2. Department of Oncology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu Province, China
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摘要

Abstract

We studied the effect of reduced glutathione on bone marrow stromal cells (BMSCs) treated with 6-hydroxydopamine (6-OHDA), which shows a toxic effect on dopaminergic neurons.The proliferation of BMSCs treated with 6-OHDA decreased, while that of BMSCs treated with reduced glutathione increased.The proliferation of BMSCs treated with both 6-OHDA and reduced glutathione was significantly higher compared with that treated with 6-OHDA alone.These findings indicate that reduced glutathione alleviates the toxic effect of 6-OHDA on BMSCs.

关键词

reduced glutathione/6-hydroxydopamine/bone marrow stromal cells/toxicity/Parkinson's disease/neurodegenerative disease/neural regeneration

Key words

reduced glutathione/6-hydroxydopamine/bone marrow stromal cells/toxicity/Parkinson's disease/neurodegenerative disease/neural regeneration

引用本文复制引用

Henghui Wang,Weifeng Luo,Xiaoxia Wang,Xiaoling Qin,Shiyao Bao..Reduced glutathione alleviates the toxic effect of 6-hydroxydopamine on bone marrow stromal cells[J].中国神经再生研究（英文版）,2011,6(22):1691-1695,5.

基金项目

Jiangsu Ordi-nary University Science Research Project,No.06XIB320097 （）

中国神经再生研究（英文版）

OACSCDSCI

ISSN：1673-5374

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