中国比较医学杂志2011，Vol.21Issue(8)：61-62,后插3,3.DOI:10.3969/j.issn.1671-7856.2011.08.015
比格犬垂体囊肿的组织形态学研究
Histological Observation on Spontaneous Hypophyseal Cyst in Beagle Dogs
胡建廷 1英永 1王韶艳 1王凤乾 1王汝霞2
作者信息
- 1. 山东省医药工业研究所,山东省化学药物重点实验室
- 2. 山东省医学科学院,山东,济南,250033
- 折叠
摘要
Abstract
Objective To study the spontaneous occurrence of hypophyseal cyst in beagle dogs and establish the backgruud information of experimental animals for good laboratory practice (GLP). Methods Sixty beagle dogs (male:female = 1∶1 ) aged 8-10 months were used in this study. The incidence of hypophyseal cyst was recorded and analyzed,and their histopathological features were examined by histopathology. Results Almost all the cysts were seen in the pars distalis hypophysis, and the wall was covered by a squamous or cuboidal epithelium. The total incidence rate of hypophyseal cyst was 23.3％. The incidence rate in females was 13.3％ and in males was 33.3％. Conclusions It is suggested that spontaneous occurrence of hypophyseal cyst in Beagle dogs should be monitored so as to provide correct histopathological backgroud information of the dogs for drug safety evaluation.关键词
比格犬/垂体囊肿/组织形态学Key words
Beagle dog/Hypophyseal cyst, spontaneous /Histomorphology分类
医药卫生引用本文复制引用
胡建廷,英永,王韶艳,王凤乾,王汝霞..比格犬垂体囊肿的组织形态学研究[J].中国比较医学杂志,2011,21(8):61-62,后插3,3.
