中国药业2011，Vol.20Issue(17)：11-13,3.
饮食对石杉碱甲缓释片药代动力学的影响研究
Effect of Food Intake on Pharmacokinetics of Huperzine A Sustained--Release Tablets in Healthy Volunteers
魏振满 1丁晋彪 1胡琳 1陈红鸽 1吴荣荣 1刘万卉 2沙春洁2
作者信息
- 1. 中国人民解放军302医院临床药理室,北京,100039
- 2. 烟台大学药学院,山东,烟台,264005
- 折叠
摘要
Abstract
Objective To assess the effect of high protein and fat diet on the pharmacokinetic profiles of Huperzine A Sustained - Release Tablets by LC - MS - MS. Methods The study was conducted according to an open,randomized,2 - period crossover design with a 7 - day washout interval,which was administrated with a Huperzine A Sustained - Release Tablets on an empty stomach or after meal. The plasma concentrations were determined by LC - MS/MS. Pharmacokinetic parameters were obtained using DAS program. Results The major pharmacokinetic parameters of the single doses study on an empty stomach and after meal were as follows: Cmax were (0. 873 ±0. 117 )ng/mL and ( 1. 07 ±0. 19 )ng/mL, tmax were ( 4. 6±2. 3 )h and ( 6. 0±1. 8 )h. AUCo_ t were ( 18. 7 ±3. 0 )ng · h/mL and ( 19. 4±3. 7 )ng · h/mL, AUC0_∞ were ( 20. 2±3. 5 )ng · h/mL and ( 20. 6±3. 9)ng · h/mL, respectively. As compared with fasting state, the relative bioavailability of fed state was determined as (97.5 ±10. 8 )％ , Cmax increased and tmax delayed slightly. Conclusion This method is sensitive,convenient and proved to be suitable for clinical investigation of huperzine A pharmacokinetics. High protein and fat diet could influence Huperzine A Sustained-Release Tablets’s tmax and Cmax slightly.关键词
石杉碱甲/药代动力学/液相色谱-串联质谱/饮食Key words
huperzine A/ pharmacokinetics/ LC - MS/MS/ diet分类
医药卫生引用本文复制引用
魏振满,丁晋彪,胡琳,陈红鸽,吴荣荣,刘万卉,沙春洁..饮食对石杉碱甲缓释片药代动力学的影响研究[J].中国药业,2011,20(17):11-13,3.
