中国神经再生研究（英文版）2011，Vol.6Issue(21)：1612-1617,6.DOI:10.3969/j.issn.1673-5374.2011.21.002
Identification of differentially expressed proteins in SH-SY5Y cells treated with resveratrol
Identification of differentially expressed proteins in SH-SY5Y cells treated with resveratrol
Ying Wang 1Zhong Dong 1Hongyan Fan 2Ming Chang 1Guoyi Li 1Linsen Hu1
作者信息
- 1. Department of Neurology, First Affiliated Hospital, Jilin University, Changchun 130021, Jilin Province, China
- 2. Department of Pharmacology, Jilin Medical College of Basic Medicine, Jilin 132011, Jilin Province, China
- 折叠
摘要
Abstract
To gain insight into the molecular mechanisms of resveratrol-mediated neuroprotection, two-dimensional difference gel electrophoresis in combination with matrix-assisted laser desorption ionization time-of-flight mass spectrometry was used to identify proteins differentially-expressed in SH-SY5Y cells treated with resveratrol. Compared with the control group, resveratrol treatment significantly affected the expression of four proteins: endoplasmic reticulum oxidoreductin 1-like protein alpha, p21-activated kinase 1, Archain 1, and T cell receptor beta chain. The former three were downregulated and the latter was upregulated. These proteins are primarily associated with endoplasmic reticulum stress, intracellular trafficking, and immune function.关键词
resveratrol/SH-SY5Y cells/two-dimensional difference gel electrophoresis/proteomics/neural regenerationKey words
resveratrol/SH-SY5Y cells/two-dimensional difference gel electrophoresis/proteomics/neural regeneration引用本文复制引用
Ying Wang,Zhong Dong,Hongyan Fan,Ming Chang,Guoyi Li,Linsen Hu..Identification of differentially expressed proteins in SH-SY5Y cells treated with resveratrol[J].中国神经再生研究（英文版）,2011,6(21):1612-1617,6.
