首页|期刊导航|中国神经再生研究（英文版）|Geniposide protects human neuroblastoma SH-SY5Y cells against corticosterone-induced injury
中国神经再生研究（英文版）2011，Vol.6Issue(21)：1618-1622,5.DOI:10.3969/j.issn.1673-5374.2011.21.003
Geniposide protects human neuroblastoma SH-SY5Y cells against corticosterone-induced injury
Geniposide protects human neuroblastoma SH-SY5Y cells against corticosterone-induced injury
摘要
Abstract
In vitro cultured human neuroblastoma SH-SY5Y cells were pretreated with 50 or 5 μg/mL geniposide for 12 hours and exposed to 400 μmol/L corticosterone. Corticosterone exposure in cultures not pretreated with geniposide resulted in inhibited cell growth, reduced cell survival, and increased P53 and P21 protein expression. However, in geniposide pretreated SH-SY5Y cells, cell viability and the number of cells in the G2 phase of the cell cycle were significantly increased, P21 and P53 protein expression was reduced, and cell apoptosis was inhibited following corticosterone exposure. These results indicate that geniposide can protect SH-SY5Y cells against high-dose corticosterone-induced injury.关键词
Geniposide/SH-SY5Y cells/corticosterone/protein expression/apoptosisKey words
Geniposide/SH-SY5Y cells/corticosterone/protein expression/apoptosis引用本文复制引用
Liping Chen,Fawei Wang,Miao Geng,Hongyan Chen,Dongmei Duan..Geniposide protects human neuroblastoma SH-SY5Y cells against corticosterone-induced injury[J].中国神经再生研究（英文版）,2011,6(21):1618-1622,5.基金项目
the Capital Specific Clinical Medical Subject of Beijing Science and Technology Commission,No.Z090507017709030 （）
