中国神经再生研究（英文版）2011，Vol.6Issue(23)：1775-1779,5.DOI:10.3969/j.issn.1673-5374.2011.23.002
BMS-345541 inhibited nuclear factor kappa B expression and improved locomotor function recovery in rats after acute spinal cord injury
BMS-345541 inhibited nuclear factor kappa B expression and improved locomotor function recovery in rats after acute spinal cord injury
Xin Han 1Shouyu Wang 1Zhen Zhang 1Decheng Lü 1Hairun Liu1
作者信息
- 1. Department of Orthopedic Surgery, First Affiliated Hospital of Dalian Medical University, Dalian 116000, Liaoning Province, China
- 折叠
摘要
Abstract
This study sought to elucidate the changes of nuclear factor kappa B (NF-κB) expression and locomotor function of hind limb after subdural injection of BMS-345541 was applied in rats with acute spinal cord injury. The results indicated that BMS-345541 treatment reduced the expression of NF-kB at 24 hours after injury, compared with normal saline-treated rats. This treatment also led to a significant improvement in locomotor functional recovery at 14 days after injury. Overall, the findings demonstrated that BMS-345541 significantly ameliorated spinal cord injury-induced hind limb dysfunction by inhibiting the expression of NF-kB after spinal cord injury.关键词
spinal cord injury/BMS-345541/nuclear factor kappa B/locomotor function/neural regenerationKey words
spinal cord injury/BMS-345541/nuclear factor kappa B/locomotor function/neural regeneration引用本文复制引用
Xin Han,Shouyu Wang,Zhen Zhang,Decheng Lü,Hairun Liu..BMS-345541 inhibited nuclear factor kappa B expression and improved locomotor function recovery in rats after acute spinal cord injury[J].中国神经再生研究（英文版）,2011,6(23):1775-1779,5.
