首页|期刊导航|中国神经再生研究（英文版）|Effect of borneol and electroacupuncture on the distribution of hyperforin in the rat brain
中国神经再生研究（英文版）2011，Vol.6Issue(24)：1876-1882,7.DOI:10.3969/j.issn.1673-5374.2011.24.007
Effect of borneol and electroacupuncture on the distribution of hyperforin in the rat brain
Effect of borneol and electroacupuncture on the distribution of hyperforin in the rat brain
摘要
Abstract
Hyperforin is an antidepressant drug that has unstable therapeutic effects, due to its poor ability to cross the blood-brain barrier. Borneol and electroacupuncture have both been found to increase the permeability of the blood-brain barrier. As such, the current study examined the distribution of hyperforin in the rat brain, and the effects on the brain distribution of hyperforin of borneol alone (orally administered), and borneol combined with electroacupuncture treatment. High-performance liquid chromatography technology and pharmacokinetic analysis revealed that treatment with borneol alone (300, 600 mg/kg) increased peak concentration and the area under the curve for hyperforin in the brain. In addition, the bioavailability of hyperforin in rat brain increased by 42.7%. However, increasing the dose of borneol dose did not appear to increase the distribution of hyperforin in the brain. Importantly, applying electroacupuncture at Baihui (GV 20) or Yamen (GV 15) appeared to enhance the brain-delivery effects of borneol, although this effect was weak. Overall, our results indicated that borneol alone or combined with electroacupuncture can provide promising strategies for brain-targeted delivery in central nervous system therapy.关键词
hyperforin/borneol/electroacupuncture/blood-brain barrier/brain targeting/neural regenerationKey words
hyperforin/borneol/electroacupuncture/blood-brain barrier/brain targeting/neural regeneration引用本文复制引用
Bin Yu,Ming Ruan,Yong Sun,Xiaobing Cui,Yun Yu,Lingling Wang,Taihui Fang..Effect of borneol and electroacupuncture on the distribution of hyperforin in the rat brain[J].中国神经再生研究（英文版）,2011,6(24):1876-1882,7.基金项目
the National Natural Science Foundation of China,No:81001651 （）
Opening Project from Key Laboratory of Integrative Acupuncture and Drugs Constructed by Jiangsu Provincial and Chinese Education Ministry,No:KJA200905 （）
