摘要
Abstract
Objective To evaluate the curative effects and safety of early tirofiban hydrochloride application on the basis of aspirin , clopidogrel, and low molecular weight heparin ( LMWH ) treatment in patients with acute coronary syndrome complicated with diabetes. Methods A total of 110 cases of hospitalized patients with acute coronary syndrome accompanied by diabetes were randomly divided into the study group ( 54 cases ) and the control group ( 56 cases ). Both groups received subcutaneous LMWH for 8 days with the study group received additional intravenously injected tirofiban hydrochloride at the same time.Results Incidence rates of all - cause death and refractory angina pectoris during the 8 days of treatment were lower in the study group than in the control group ( P＜0.05 ), while rates of recurrent myocardial infarction were not statistically different between the two groups ( P ＞ 0.05 ). No case of severe - hemorrage was observed for both groups; numbers of non - hemorrhage, mild -hemorrage , and moderate - hemorrage cases were found to be 35 , 15 , and 4 in the study group and 48 , 2, and 6 in the control group respectively, with significant differences between the two groups ( u =2.493 , P ＜ 0.05 ). The platelet count in the study group decreased significantly after treatment compared with before ( P ＜ 0.05 ) , while still in normal range and was not significantly different from that of the control group ( P ＞ 0.05 ). Conclusion It is both effective and safe of tirofiban hydrochloride to treat patients with acute coronary syndrome and complicated diabetes on the basis of aspirin, clopidogrel, and low molecular weight heparin ( LMWH ) treatment.关键词
替罗非班/急性冠脉综合征/糖尿病/出血/治疗结果Key words
Tirofiban/ Acute coronary syndrome/ Diabetes mellitus/ Hemorrhage/ Treatment outcome分类
医药卫生
