肿瘤防治研究2011，Vol.38Issue(8)：926-929,4.DOI:10.3971/j.issn.1000-8578.2011.08.018
肝癌衍生生长因子在乳腺癌中的表达及其临床意义
Hepatoma-Derived Growth Factor Expression and Its Clinical Significance in Breast Cancer
潘宇亮 1曹培国 1张隽 1符慧群1
作者信息
- 1. 410013,长沙,中南大学湘雅三医院肿瘤科
- 折叠
摘要
Abstract
Objective To evaluate the expression of Hepatoma-derived growth factor (HDGF) and its clinical implication in breast cancer. Methods The expression of HDGF was detected by immunohistochemical method in 113 breast cancer and 32 breast hyperplasia tissues. At the same time, the expressions of human epidermal growth factor receptor 2 ( HER-2), estrogen recaptor(ER) and progesterone (PR) were detected in breast cancer. The relationships between HDGF, ER, PR and HER-2 with clinical data were analyzed by multivariate analysis and Kaplan-Meier. Results Over-expression rate of HDGF in breast cancer tissues was higher than that in breast hyperplasia tissues(P＜0. 01). There were no relationship between the expression of HDGF and age, pathological type, menostasis, ER and PR expression(P＞0. 05). However, HDGF expression was significantly correlation with tumor size, lymphnode metastasis, distant metastasis and HER-2 expression (P＜0. 01 or 0. 05). Patients with low HDGF expression had a higher 5-year survival rates than those with HDGF over-expression (P＜0. 01). Multivariate analysis showed that HDGF was an important prognostic factor for breast cancer(RR = 1. 263, P＜0.05). Conclusion The over-expression of HDGF was a novel biomarker involved in the poor prognosis of breast cancer.关键词
乳腺癌/肝癌衍生生长因子/人类表皮生长因子受体2Key words
Breast cancer/ Hepatoma-derived growth factor/ Human epidermal growth factor receptor 2分类
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潘宇亮,曹培国,张隽,符慧群..肝癌衍生生长因子在乳腺癌中的表达及其临床意义[J].肿瘤防治研究,2011,38(8):926-929,4.
