磁共振成像2011，Vol.2Issue(5)：325-330,6.DOI:10.3969/j.issn.1674-8034.2011.05.002
靶向对比剂CLT1-(Gd-DTPA)在小鼠乳腺癌磁共振分子成像效果的研究
Evaluation of CLT1-(Gd-DTPA) for MR molecular imaging in a mouse breast cancer model
摘要
Abstract
A peptide targeted contrast agent, CLT1-(Gd-DTPA), was investigated for molecular imaging of fibrin-fribronectin complexes in tumor stroma with magnetic resonance imaging (MRI). The contrast agent was evaluated in female nude mice bearing MDA-MB-231 human breast carcinoma xenografts on a Siemens 3T clinical scanner with a clinical agent Gd (DTPA-BMA) as a non-targeted control. CLT1-(Gd- DTPA) specifically bound to tumor tissue and resulted in significant tumor contrast enhancement at a dose of 0.05 mmol/kg for at least 60 minutes after injection. In contrast, a non-targeted contrast agent, Gd(DTPA-BMA), cleared rapidly from the body with little tumor enhancement after 30 minutes post-injection at a dose of 0.1 mmol/kg. CLT1-(Gd-DTPA) had little non-specific binding in blood and normal tissues, including the liver and muscle, resulting in comparable non-specific enhancement in normal tissues to the control agent. The study has shown that CLT1-(Gd-DTPA) can bind to the tumor tissue, resulting in significant tumor enhancement in a mouse breast cancer model. The targeted contrast agent has a potential for MR molecular imaging of breast cancer.关键词
磁共振成像/分子成像/对比剂/小鼠/乳腺癌Key words
Magnetic resonance imaging/Molecular imaging/Targeted contrast agent/Mouse/Breast cancer分类
医药卫生引用本文复制引用
Furong Ye,Eun-Kee Jeong,Denis Parker,Zheng-Rong Lu..靶向对比剂CLT1-(Gd-DTPA)在小鼠乳腺癌磁共振分子成像效果的研究[J].磁共振成像,2011,2(5):325-330,6.基金项目
本研究受美国国立卫生研究院(US NIHR01 CA097465)资助. （US NIHR01 CA097465）
