中国药理学通报2011，Vol.27Issue(10)：1342-1345,4.DOI:10.3969/j.issn.1001-1978.2011.10.003
星形胶质细胞在脑缺血中的变化和作用
Change and role of astrocyte in cerebral ischemia
摘要
Abstract
Astrocytes, the maior glial cells in the central nervous system , proliferate and hypertrophy , expressions of glial fibrillary acidic protein and vimentin significantly increase in cerebral ischemia. Astrocytes have a stronger tolerance in ischemia and protect neurons through multiple pathways. On the other hand,astrocytes injure neuron by releasing excitatory amino acids, inflammatory mediators and decreasing gap junction. Therefore, astrocyte has a dual role in ischemic injury. Clarifying the role of astrocyte in cerebral ischemia and its mechanism may provide a novel target for the treatment of cerebral ischemia.关键词
星形胶质细胞/神经元/脑缺血/神经保护/毒性损伤/机制研究Key words
astrocyte/ neuron/ cerebral ischemia/ neuroprotection/ toxicity damage/ mechanism分类
医药卫生引用本文复制引用
牛非,胡金凤,苑玉和,韩宁,陈乃宏..星形胶质细胞在脑缺血中的变化和作用[J].中国药理学通报,2011,27(10):1342-1345,4.基金项目
国家自然科学基金资助项目(No 30801527,81073078,81073130,30973887,U832008,90713045) （No 30801527,81073078,81073130,30973887,U832008,90713045）
国家创新药物研究重大专项资助项目(No 2009ZX09303,2009ZX09301) （No 2009ZX09303,2009ZX09301）
