临床与实验病理学杂志2011，Vol.27Issue(9)：929-932,4.
浸润性乳腺癌HDAC1mRNA表达的临床病理意义
The clinicopathological significance of HDAC1 mRNA expressing in invasive breast cancers
摘要
Abstract
Purpose To study the expression of histone deacetylase 1 ( HDAC1 ) protein and mRNA in invasive breast cancer and the correlation with clinicopathologic features. Methods HDAC1 protein and mRNA expression were delectded by immunohistochemistry and RT-PCR method in breast cancer and benign breast, and studied the relationship with clinicopathological features and Her-2 protein expression. Results ( 1 ) HDAC1 protein expression rate was 35. 83％( 43/120 ) in breast cancer. there is low expression or no expression in 20 cases of breast hyperplasia, and the significant differences between them. ( 2 )HDAC1 mRNA positive rate was 63. 33％ ( 38/60 ) which it was higher than immunohistochemistry. ( 3 )The correlation was found between HDAC1 and Her-2( 55. 26％ ) in breast cance( P ＜0. 08 ). Conclusions ( 1 )There was difference between breast cancer and breast benign proliferative lesions in HDAC1 protein expression. HDAC1 may play an important role in the development of invasive breast cancer and it is a valuable prog nostic marker. ( 2 )The results tested by RT-PCR are more sensitive than immunohistochemistry. ( 3 )HDAC1 inhibitors was expected to become a new targeted therapy drugs for breast cancer patients.关键词
乳腺肿瘤/组蛋白去乙酰化酶1 mRNA/RT-PCR/免疫组化Key words
breast neoplasms/ histone deacetylase 1 mRNA/ RT-PCR/ immunohistochemistry分类
医药卫生引用本文复制引用
杨书云,李海波,张建兵..浸润性乳腺癌HDAC1mRNA表达的临床病理意义[J].临床与实验病理学杂志,2011,27(9):929-932,4.基金项目
南通市科技局社会发展计划(S2007012) （S2007012）
