山西医科大学学报2011，Vol.42Issue(9)：710-713,4.DOI:10.3969/J.ISSN.1007-6611.2011.09.004
慢性乙型肝炎患者196例病毒基因分型与临床的关系
Genotypes of hepatitis B virus in 196 patients with chronic infection and its relationships with clinical features
摘要
Abstract
Objective To investigate the distrihution and clinical significance of hepatitis B virus genotypes in patients with chronic infection in Xi' an Central Hospital. Methods Nested PCR with genotype specific primers was used to determine the genotype in 196 chronic HBV patients. The clinical features of patients with HBV genotype were analyzed. Results Of 196 patients , 138( 70. 4％were diagnosed with genotype C ,40( 20. 4％ )with genotype B ,18( 9. 2％ ) with mixed genotype B and C. The distribution of genotypes was not different between male and female in 196 patients( P ＞ 0. 05 ). There was no significant difference among the patients with chronic hepatitis,liver cirrhosis,hepatocelluar carcinoma and chronic asymptomatic HBV carriers. HBeAg positive rate of genotype C patients was significantly higher than that of genotype B( 75. 2％ vs 14. 2％ ,P ＜0. 05 ). The level of ALT and HBV-DNA was not significantly different among patients with genotype C,B and mixed B/C( P ＞0. 05 ). Conclusion The predominant HBV genotypes in Xi'an Central Hospital, are confirmed to be genotype C and genotype B. HBeAg positive rate of genotype C patients is higher than that of genotype B. Patients with genotype B and genotype C have no difference in the severity of liver disease and HBV-DNA.and have similarclinic:al features.关键词
乙型肝炎病毒/基因型/聚合酶链反应Key words
hepatitis B virus/ genotype/ polymerase chain reaction分类
医药卫生引用本文复制引用
付建军,白艳丽,王巧侠,赵怡生,赵英仁,李建元..慢性乙型肝炎患者196例病毒基因分型与临床的关系[J].山西医科大学学报,2011,42(9):710-713,4.基金项目
陕西省科技厅社会发展计划项目2007K-14-02-(18) （18）
