中国组织工程研究与临床康复2011，Vol.15Issue(37)：6927-6931,5.DOI:10.3969/j.issn.1673-8225.2011.37.021
准分子激光角膜上皮瓣下磨镶术中角膜上皮瓣的活性
Viability of corneal epithelial flap in laser subepithelial keratomileusis
陈颖欣 1高明宏 1袁月1
作者信息
- 1. 解放军沈阳军区总医院眼科,辽宁省沈阳市,110840
- 折叠
摘要
Abstract
BACKGROUND: The optimum ethanol exposure time to ensure the viability of corneal epithelial flap is the research hotspot forlaser subepithelial keratomileusis.OBJECTIVE: To investigate the factors influencing the viability of corneal epithelial flap in laser subepithelial keratomileusis(LASEK).METHODS: A standard LASEK was performed on 100 eyes of 50 myopic patients prospectively. The preoperative sphericalequivalent ranged from -1.37 m-1 to -6.00 m-1, with the mean value of (-4.09 m-1±2.12 m-1). Eyes were divided to two groups, lowmyopic group A (＜-3.00 m-1, 40 eyes) and moderate myopic group B (-3.00 m-1-6.00 m-1, 60 eyes). All of the eyes were exposedto 20％ ethanol for 15 and 25 seconds, so group A was divided to group A1(15 seconds) and group A2 (25 seconds) (20 eyes foreach group), and group B was divided to group B1 (15 seconds) and group B2 (25 seconds) (30 eyes for each group).Uncorrected visual acuity (UCVA) and corneal fluorescein staining and corneal haze were noticed and compared at the 12months of follow-up.RESULTS AND CONCLUSION: The healing time of epithelium of gro up A1 was significantly longer than that of group A2, andthe healing time of epithelium of group B1 was significantly longer than that of group B2 (P ＜ 0.01). In terms of Haze grade 2,there was significant difference between group A1 and group A2 (P ＜ 0.05) and between group B1 and group B2 (P ＜ 0.01).Score of corneal fluorescein staining was positively correlated with Haze frequency. Under corresponding cutting depth of cornealmatrix in LASEK, we obtained high quality and fine viability of corneal epithelial lap if we shortened the ethanol expose time, sowe were satisfied with the healing time of cornea and vision and decreased frequency of Haze. These findings suggest that in theLASEK, under proper cutting depth of corneal matrix, shorter ethanol expose time leads to better quality of corneal epithelial flapprepared, better flap viability, and faster healing, which contribute to recovery of vision.关键词
角膜屈光手术/角膜上皮瓣/角膜雾状混浊/角膜荧光素染色/乙醇/近视分类
基础医学引用本文复制引用
陈颖欣,高明宏,袁月..准分子激光角膜上皮瓣下磨镶术中角膜上皮瓣的活性[J].中国组织工程研究与临床康复,2011,15(37):6927-6931,5.
