肿瘤预防与治疗2011，Vol.24Issue(5)：221-224,4.DOI:10.3969/j.issn.1674-0904.2011.05.003
地塞米松不同给药方式治疗大鼠放射性直肠炎疗效观察
Evaluation of the Effects of Dexamethasone on Rat Radiation-induced Proctitis by Different Administration Methods
敖睿 1孙岚 2刘浩 1涂琳莉2
作者信息
- 1. 四川省人民医院肿瘤科,成都,610072
- 2. 四川大学华西医院肿瘤中心,成都,610041
- 折叠
摘要
Abstract
Objective : To compare the effect of dexamethasone on rat radiation-induced proctitis administrated by two different ways which were the intraperitoneal injection and clyster. Methods: Thirty-two SD rats were randomly divided into 4 groups, which were defined as follows : unirradiated and clystered by normal saline( group A ); irradiated and clystered hy normal saline( group B );irradiated and clystered by dexamethasone( group C ) ; irradiated and dexamethasone was given by intraperitoneal injection ( group D ).The pelvis of rats received irradiation with a dose of 16. 5Gy except group A. All rats were killed ten days after irradiation. The levels of radiation-induced proctitis were scored after HE staining of the rectum. and the expression of serum TNF-α was detected by ELISA method and TNF-α mRNA expression level of the rectum was detected by RT-PCR. Results: Dexamethasone showed good effects to treat radiation-induced proctitis by intraperitoneal injection as well as reduce the expression of TNF-α of the serum and the TNF-α mRNA level of rectum, while it demonstrated no effect on radiation-induced proctitis when administrated bv clvsis. Conclusion: It is a right way for dexamethasone to treat radiation-induced proctitis by systemic administration .关键词
放射性直肠炎/地塞米松/灌肠/腹腔注射Key words
Radiation Proctitis/ Dexamethasone/ Clyster/ Intraperitoneal Injection分类
医药卫生引用本文复制引用
敖睿,孙岚,刘浩,涂琳莉..地塞米松不同给药方式治疗大鼠放射性直肠炎疗效观察[J].肿瘤预防与治疗,2011,24(5):221-224,4.
