中国组织工程研究与临床康复2011，Vol.15Issue(37)：6841-6845,5.DOI:10.3969/j.issn.1673-8225.2011.37.001
阿仑膦酸钠可抑制骨质疏松性骨折的愈合
Alendronate sodium inhibits femoral fracture healing in osteoporosis rats
骆阳 1张柳 2宋亚琪 2田发明 2程谭2
作者信息
- 1. 河北医科大学,河北省石家庄市,050051
- 2. 河北联合大学附属医院骨外科,河北省唐山市,063000
- 折叠
摘要
Abstract
BACKGROUND: Alendronate sodium has been preferred for clinical treatment of osteoporosis.OBJECTIVE: To investigate the effects of alendronate sodium on femoral shaft fracture healing in rats with osteoporosis.METHODS: The rats were randomly divided into three groups: sham surgery, model and alendronate sodium. The right femoraldiaphysis of rats in the model and alendronate sodium groups was fractured transversely at the midshaft and fixed with Kirschnerwire at 4 weeks after ovariectomy. The alendronate sodium group rats were subcutaneously administered alendronate sodiumafter fracture establishment.RESULTS AND CONCLUSION: At 3 and 6 weeks after fracture establishment, the bone mineral density of the whole femur anddistal-segment femur was significantly greater in the alendronate sodium group than in the model group (P < 0.01). Comparedwith model group, the callus volume was greater, the conversion process of cartilaginous callus towards osseous callus wasdecreased, femoral fracture healing was slowed, and the number of osteoclasts was significantly decreased (P < 0.05) in thealendronate sodium group. The results demonstrated that alendronate sodium inhibited fracture healing in rats with osteoporosis,and the underlying mechanism may be related to a fact that alendronate sodium inhibits the activity osteoclasts, which slows thecallus calcification process.关键词
阿仑膦酸钠/骨质疏松性骨折/卵巢切除/愈合/破骨细胞/骨形态发生蛋白/血管内皮生长因子/骨组织工程分类
医药卫生引用本文复制引用
骆阳,张柳,宋亚琪,田发明,程谭..阿仑膦酸钠可抑制骨质疏松性骨折的愈合[J].中国组织工程研究与临床康复,2011,15(37):6841-6845,5.
