中国组织工程研究与临床康复2011，Vol.15Issue(37)：7000-7004,5.DOI:10.3969/j.issn.1673-8225.2011.37.038
基底膜蛋白多糖的功能多样:血管发生与软骨形成及软骨骨化
Multi-functional perlecan:angiogenesis,chondrogenesis and chondrosteosis
摘要
Abstract
BACKGROUND: Perlecan functions in a diverse range which ranges from the regulation of cell growth and adhesion toextracellular matrix assembly. We previously identified a central function for perlecan during angiogenic blood vessel developmentand injury restoration.OBJECTIVE: To explore the mechanism of perlecan in tissue development and organogenesis.METHODS: A computer-based retrieval was performed to search manuscripts published between January 2000 and December2010 in Sciencedirect and CMCC/CMCI with key words of “perlecan, angiogenesi s, cartilage, heparan sulfate, vascular endothelialgrowth factor.” The manuscripts with the contents of perlecan expression and function published recently or in authoritative journalswere included. Manuscripts with repetitive contents or Meta analysis were excluded.RESULTS AND CONCLUSION: A total of 129 manuscripts were included, and according to inclusion and exclusion criteria, 35manuscripts were included in the final analysis. Perlecan plays a crucial role in tissue development. The underlying mechanism ispossibly due to the interactions of the pericellular environment. Perlecan functions in a diverse range. Perlecan employs the samebasic mechanism, based on interactions with growth factors, morphogens and matrix proteins.关键词
基底膜蛋白多糖/血管发生/软骨/生长因子/成釉器/牙本质分类
医药卫生引用本文复制引用
徐柯,陈吉华,唐立辉,吴丹..基底膜蛋白多糖的功能多样:血管发生与软骨形成及软骨骨化[J].中国组织工程研究与临床康复,2011,15(37):7000-7004,5.基金项目
本课题受国家自然科学基金(30770572)资助,名称:应用重组PlnDI构建自组装促血管发生材料. （30770572）
