中国组织工程研究与临床康复2011，Vol.15Issue(38)：7123-7126,4.DOI:10.3969/j.issn.1673-8225.2011.38.021
原位定型微囊化载体制剂在糖尿病大鼠皮肤溃疡中的作用
Therapeutic effect of microencapsulation carrier preparation for in situ stereotype on skin ulcers of diabetic rats
王晓梅 1王府 2杨晓辉 2金成吉 1李湘1
作者信息
- 1. 大连大学附属中山医院内分泌科,辽宁省大连市,116001
- 2. 金乡县人民医院内分泌科,山东省济宁市,272200
- 折叠
摘要
Abstract
BACKGROUND: Insulin as one of the components of microencapsulation carrier preparation for in situ stereotype can promotethe ulcer healing.OBJECTIVE: To evaluate the therapeutic effect of microencapsulation carrier preparation for in situ stereotype on skin ulcers ofdiabetic rats.METHODS: Sprague-Dawley (SD) rats were used to establish diabetic rat models by intraperitoneal injection of streptozotocin(STZ) and to set up skin ulcer models by surgical methods. All rats were randomly divided into 4 groups by different interventions:microencapsulation preparation with effective component group (MPE), microencasultion preparation without effectivecomponent group (MPNE), general preparation with effective component group (GE), blank control group (BC). Ulcer area wasmeasured at regular time intervals. In the first 14 days, full-thickness skin wounds were brought to make histological observationand determine the positive cell numbers expressing epidermal growth factor receptor (EGFR) and fibronectin (FN) .RESULTS AND CONCLUSION: The skin ulcer healing time of MPE group was the shortest compared with the other threegroups (P ＜ 0.05 or P ＜ 0.01). The number of EGFR and FN positive cells in MPE group was more than that of any other threegroups (P ＜ 0.05 or P ＜ 0.01). Microencapsulation carrier preparation for in situ stereotype can promote the healing course of skinulcer in diabetic rats.关键词
微囊化载体制剂/糖尿病大鼠/皮肤溃疡/表皮生长因子受体/连接蛋白分类
医药卫生引用本文复制引用
王晓梅,王府,杨晓辉,金成吉,李湘..原位定型微囊化载体制剂在糖尿病大鼠皮肤溃疡中的作用[J].中国组织工程研究与临床康复,2011,15(38):7123-7126,4.
