实用肝脏病杂志2011，Vol.14Issue(5)：351-353,3.DOI:10.3969/j.issn.1672-5069.2011.05.013
血清视黄醇结合蛋白4对非酒精性脂肪性肝炎的诊断价值
Significance of serum retinol-binding protein 4 in the diagnosis of patients with nonalcoholic steatohepatitis
李丽 1闵若谦 1展玉涛 2赵淑杰1
作者信息
- 1. 100123,北京市民航总医院体检康复中心
- 2. 首都医科大学附属北京同仁医院消化内科
- 折叠
摘要
Abstract
Objective To evaluate the clinical significance of serum retinol- binding protein 4 (RBP4)in the diagnosis of patients with nonalcoholic steatohepatitis (NASH). Methods Serum RBP4 was measured in triplicates by a specific enzyme-linked immunosorbent aSSay in 42 biopsy- proven patients with NASH,28 with fatty liver and 20 healthy people. The diagiostic performance of the serum RBP4 was assessed by analysis of receiver operating characteristic (ROC)curve. Results Serum RBP4 level in the NASH was 37.11±7.68mg/L,significantly higher than that in the Smple steatosis cases (22.83±6.33mg/L,P＜0.01)or in control subjects (19.38±5.46mg/L,P＜0.01) ; The area under the curve for serum RBP4 were 0.804 and the senstivity and specificity for diagiosis of NASH were 79.6％ 和 76.6％,respectively. Conclusion This study demonstrates that serum RBP4 levels may be a senstive marker to detect patients with NASH.关键词
非酒精性脂肪性肝炎/血清视黄醇结合蛋白4/诊断Key words
Nonalcoholic steatohepatitis/ Retinol- binding protein 4/ Diagiosis引用本文复制引用
李丽,闵若谦,展玉涛,赵淑杰..血清视黄醇结合蛋白4对非酒精性脂肪性肝炎的诊断价值[J].实用肝脏病杂志,2011,14(5):351-353,3.
