中国妇幼健康研究2011，Vol.22Issue(5)：682-684,3.DOI:10.3969/j.issn.1673-5293.2011.05.047
增量阿托伐他汀对女性急性冠脉综合征患者CPR的影响
Effect of high dose atorvastatin on C-reactive protein level in female acute coronary syndrome
黄旭英 1卓鹏展 1吴涛2
作者信息
- 1. 西安市铁路医院心血管内科,陕西,西安,710004
- 2. 西安医学院附属医院普外科,陕西,西安,710077
- 折叠
摘要
Abstract
Objective To explore the effect of high dose and routine dose atorvastatin on serum C-reactive protein ( CRP ) level in female acute coronary syndrome ( ACS ). Methods 96 female patients with ACS were randomly divided into routine dose treatment group ( n = 48,atorvastatin 20mg/d ) and high dose treatment group ( n = 48, atorvastatin 40mg/d ), and 50 healthy females were selected as the control group. Atovastatin was administered within 24 hours in treatment groups. The serum CRP levels of all the cases were determined before therapy and 28 days after atovastatin treatment. Results The serum CRP levels in high dose treatment group decreased from 8.58 ± 1.45mg/L before treatment to 4.32 ± 1.02mg/L after treatment, and those in routine dose treatnent group decreased from 8.52 ± 1.58ng/L to 6.48 ± 0. 70mg/L. The CRP level decreased in high dose treatment group was significantly different from that in routine dose treatment group ( t =2. 9370,P ＜0.05 ). Conclusion High dose of atovastatin can reduce CRP level in female ACS significantly, and the effect is better than routine dose, which has significant value for prognosis of ACS.关键词
女性急性冠脉综合征/炎症/C反应蛋白/阿托伐他汀Key words
female acute coronary syndrome /inflammation /Creactive protein ( CRP )/atorvastatin分类
医药卫生引用本文复制引用
黄旭英,卓鹏展,吴涛..增量阿托伐他汀对女性急性冠脉综合征患者CPR的影响[J].中国妇幼健康研究,2011,22(5):682-684,3.
