医药导报2011，Vol.30Issue(10)：1266-1269,4.DOI:10.3870/yydb.2011.10.003
槲皮素长循环纳米脂质体的小鼠口服吸收研究
Oral Absorption of Long Circulating Nano-liposomes of Quercetin in Mice
摘要
Abstract
Objective To prepare long circulating nano-liposomes of quercetin( QUE-LCL ) and investigate the physical and chemical properties and oral absorption in mice. Methods The QUE-LCL was prepared by the emulsified evaporation-low temperature solidification method with Glyceryl bebenate( ATO ) and Tween 80 as carriers and the optimum formulation selected by orthogonal test. Its morphology was examined by transmission electron microscope( TEM ) and the particle diameter distribution was detected. The quereetin determination in nanoparticles and the mixture of gastrointestinal contents and feces by HPLC were established. Results QUE-LCL was spherical shape with mean diameter of 172. 63 nm and entrapment efficiency was 91.77％ . The oral absorption of QUE-LCL in mice was better than that of quercetin suspension and common liposomes.Conclusion The emulsified evaporation-low temperature solidification is suitahle for preparing QUE-LCL, and the preparation of which made by orthogonal test promotes the oral absorption of quercetin in mice.关键词
槲皮素/脂质体,纳米,长循环/色谱法,高效液相/口服吸收Key words
Quercetin / Liposomes , nano , long circulating / HPLC / Oral absorption分类
医药卫生引用本文复制引用
王刚,常明泉,杨光义,曾南,叶方..槲皮素长循环纳米脂质体的小鼠口服吸收研究[J].医药导报,2011,30(10):1266-1269,4.基金项目
湖北省教育厅优秀中青年基金资助项目(基金编号:Q20102110) （基金编号:Q20102110）
