医药导报2011，Vol.30Issue(10)：1273-1274,2.DOI:10.3870/yydb.2011.10.005
鬼针草总黄酮对体外血小板聚集的影响
Effects of Total Flavones from Bidens Bipinnata L.on Platelet Aggregation in vitro
潘海敏 1方慧华 1严士海2
作者信息
- 1. 江苏省中医院药剂科,南京,210029
- 2. 江苏省中医院科技处,南京,210029
- 折叠
摘要
Abstract
Objective To investigate the effects of total flavones from Bindens bipinnata L. on rabbit platelet aggregation. Methods Platelet aggregation was induced by adenosine diphoshate ( ADP ) or thrombase ( Thr ), the inhibitory effects and dose-dependent relationship of total flavones from Bindeas bipinnata L. were observed in vitro by turbidimetric method.Results The high and middlle dose of total flavones from Bindens bipinnata L. significantly suppressed the maximum platelet agglutination induced by ADP ( P＜0.01 ), while the blocking rate of blood platelet aggregation was 45.82％ and 28.65％ ,respectively. Additionally, these two doses of total flavones also demonstrated a strong restriction on the maximum platelet agglutination induced by Thr ( P＜0.01 ), in which the curbing rate of blood platelet aggregation was reached to 48.36％ and 33.82％ , respectively. Total flavones exhibit a dose dependent manner. Conclusion Total flavones from Bindens bipinnata L. possesses powerful inhibitory abilities against the platelet aggregation induced by ADP and Thr in vitro.关键词
鬼针草总黄酮/血小板聚集/二磷酸腺苷/凝血酶Key words
Total flavones from Bidens bipinnata L./ Platelet aggregation/ Adenosine diphosphate/ Thrombase分类
医药卫生引用本文复制引用
潘海敏,方慧华,严士海..鬼针草总黄酮对体外血小板聚集的影响[J].医药导报,2011,30(10):1273-1274,2.
