浙江医学2011，Vol.33Issue(9)：1263-1264,1268,3.
急性冠状动脉综合征非介入患者强化阿托伐他汀治疗疗效观察
The clinical study on the efficacy of intensive lipid-lowering therapy in patients with Non-ST-segment elevation acute coronary syndromes
成银宏 1傅国胜 1唐欧杉 2陈钟良 2秦丰明2
作者信息
- 1. 310016,杭州,浙江大学医学院附属邵逸夫医院心内科
- 2. 绍兴第二医院心内科
- 折叠
摘要
Abstract
Objective To study the clinical efficacy and safety of atorvastatin (40mg/day)in patients with non- ST- segment elevation acute coronary syndromes (NSTE- ACS). Methods 68 cases of NSTE- ACS patients, were randomly divided into treatment group 34 cases and the control group 34 cases.Two groups of patients had conventional treament(aspirin ,isosorbide mononitrate,clopidogrel,etc. ).Patients in the treatment group took atorvastatin 40 mg per day for one month, then 20 mg to maintain, while patients in the controlgroup took atorvastatin 10 mg per day at all time.The course of treatment lasted 6 months.Blood cholesterol, liver function, high reactive c- reactive protein (hs- CRP) changes were recorded before treatments and after 1 month, 3 months, 6 months of treatments . Anginapectoris as well as serious cardiovascular events (recurrence myocardial infarction,cardic death,severe heart failure,ect), were also recorded. Results The total cholesterol, low density lipoprotein cholesterol (LDL- C) and hs- CRP were significantly improved in both two groups after 6 months of treatment (P＜0.05 or 0.01). The incidence of adverse cardiovascular events was significantly lower in intensive group during treatment (P＜0.05). Frequency and duration of angina pectoris were also decreased in both groups (P＜0.05), especially in intensive group (P＜0.05).Lower incidence of adverse cardiovascular events was found after discharge from hospital in intensive group (P＜0.01). Conclusion Intensive lipid- lowering therapy with atorvastatin in NSTE- ACS patients who did not receive reascularization treatment can obviously improve the clinical symptoms, reduce the complications and serious cardiovascular events.And a large dose of atorvastatin can gain greater benefits and is also safety.关键词
非ST段抬高/急性冠脉综合征/强化降脂/阿托伐他汀Key words
Non- st- segment elevation/ Acute coronary syndromes/ Intensive lipid- lowering therapy/ Atorvastatin引用本文复制引用
成银宏,傅国胜,唐欧杉,陈钟良,秦丰明..急性冠状动脉综合征非介入患者强化阿托伐他汀治疗疗效观察[J].浙江医学,2011,33(9):1263-1264,1268,3.
