浙江医学2011，Vol.33Issue(9)：1332-1323,1375,3.
PTEN和COX-2在前列腺癌中的表达及其与肿瘤血管生成的关系
Relation between the expression of PTEN,COX-2 and angiogenesis in prostate cancer using tissue microarray
摘要
Abstract
Objective To investigate the expression of PTEN and COX- 2 in prostate cancer and their relationship with angiogenesis.Methods The expressions of PTEN,COX- 2 and CD34 in 60 PCa samples were analysed by tissue microarray technology and immunohistochemistry,and compared with those of 25 BPH samples.Results The expressions of PTEN were observed in 33.3％,50.0％ and 100％ of PCa,HPIN and BPH respectively (P＜0.05),and those of COX- 2 were 66.7％,42.9％ and 4.0％ respectively (P＜0.05).The expression of COX- 2 increased with the increases of Gleason degree and clinical staging (P ＜0.05), while more loss of PTEN with the increases of Gleason degree and clinical staging (P＜0.05).The expression of PTEN was negatively related to COX- 2 in PCa.Of the PCa samples,MVD counting in PTEN negative group or COX- 2 positive group was higher than that in PTEN positive group or COX- 2 negative group (P＜0.05).Conclusion PTEN and COX- 2 proteins are significantly correlated with clinic opathological characteristics and biologic behaviours in PCa,and they may play a role in angiogenesis.关键词
前列腺肿瘤/PTEN/COX-2/微血管密度/组织芯片Key words
Prostatic neoplasms / PTEN / Cyclooxygenase(COX-2) / Microvascular density(MVD) / Tissue microarray引用本文复制引用
徐元成,徐炜炜,杨周亮..PTEN和COX-2在前列腺癌中的表达及其与肿瘤血管生成的关系[J].浙江医学,2011,33(9):1332-1323,1375,3.
