肿瘤防治研究2011，Vol.38Issue(8)：871-874,4.DOI:10.3971/j.issn.1000-8578.2011.08.005
白藜芦醇对小鼠Lewis肺癌细胞生长的抑制作用及其机制
Inhibitory Effects of Resveratrol on Growth of Lewis Lung Cancer Cell in Mice and Possible Mechanism
摘要
Abstract
Objective To explore the inhibitory effects of resveratrol(Res) on growth of Lewis lung cells in mice and the underlying mechanism. Methods Thirty-two C57BL mice inoculated Lewis lung cancer cell were randomly divided into 4 groups (each group with 8 mice): control group, low-dose Res group,high-dose Res group and cisplatin group(positive control). Different treatments were administrated from day 4 to day 17 after inoculation, then all mice were sacrificed. The tumors were removed and weighed to calculate inhibitory rate. Expression of macrophage migration inhibitory factor(MIF) was detected by western blot. Apoptotic index of tumor cells was determined by TUNEL assay. Results The inhibitory rates were 11.54％, 54. 58％ and 62. 32％ in low-dose Res group, high-dose Res group and cisplatin group respectively. Tumor weight and levels of MIF protein expression were significantly lower in highdose Res group and cisplatin group compared with control group(P＜0. 01 ) . Apoptotic index was enhanced in high-dose Res group and cisplatin group than that in control group(P＜0. 01 ). Conclusion Res had a strong inhibitory effects on growth of Lewis lung cancer by inhibition of MIF protein expression and induction of tumor cell apoptosis.关键词
肺癌/白藜芦醇/巨噬细胞移动抑制因子/细胞凋亡Key words
Lung cancer/ Resveratrol/ Macrophage migration inhibitory factor/ Cell apoptosis分类
医药卫生引用本文复制引用
杨凯,贺兼斌,张平..白藜芦醇对小鼠Lewis肺癌细胞生长的抑制作用及其机制[J].肿瘤防治研究,2011,38(8):871-874,4.基金项目
湖南省卫生厅科研基金资助项目(C2005033) （C2005033）
