中国临床药理学与治疗学2011，Vol.27Issue(7)：807-811,5.
替罗非班对急性ST段抬高型心肌梗死并糖尿病患者急诊经皮冠状动脉介入治疗术后血清MMP-9水平的影响及临床意义
Effect and clinical significance of tirofiban on serum matrix metalloproteinase 9 after primary percutaneous coronary intervention in patients with acute ST-segment elevation myocardial infarction and diabetes
摘要
Abstract
AIM: To study the effect and clinical significance of tirofiban on serum matrix metalloproteinase 9 (MMP-9) and after primary percutaneous coronary intervention (PCI) in patients with acute ST-segment elevation myocardial infarction (STEMI) and diabetes. METHODS: One hundred and twenty-three patients with acute STEMI and diabetes who were treated with primary PCI were designed into two groups: routine treatment group(61 cases) and tirofiban group(62cases). The clinical datas and coronary arterydisorders datas in two groups were compared. The serum MMP-9 levels among two groups before and after primary PCI were detected, as well as the incidences of in-stent restenosis(ISR) at 12 months after primary PCI.RESULTS:The clinical datas,the degreee of coronary stenosis and the number of lesion vessels were similar between the two groups(P＞0.05).The levels of MMP-9 in the two groups were both significantly higher after PCI (P ＜ 0.05).The level of MMP-9 after PCI from the tirofiban group was obviously lower than that in the routine treatment group ( P ＜ 0.05). The incidence of in-stent restenosis (ISR) from the tirofiban group was distinctly lower than that in the routine treatment group(P＜0.05). CONCLUSION:The level of serum MMP-9 is higher after the primary PCI in patients with acute STEMI and diabetes. The tirofiban can reduce the incidence of post-stenting restenosis by the means of degrading the level of MMP-9.关键词
替罗非班/心肌梗死/糖尿病/经皮冠状动脉介入治疗/基质金属蛋白酶-9Key words
Tirofiban/Myocardial infarction/Diabetes/ Primary percutaneous coronary intervention/ Matrix metalloproteinase-9分类
医药卫生引用本文复制引用
邓少雄,郭南鸥,郑渊,黄文森..替罗非班对急性ST段抬高型心肌梗死并糖尿病患者急诊经皮冠状动脉介入治疗术后血清MMP-9水平的影响及临床意义[J].中国临床药理学与治疗学,2011,27(7):807-811,5.基金项目
泉州市科技局基金资助项目(2007251) （2007251）
