重庆医学2011，Vol.40Issue(28)：2825-2826,2829,3.DOI:10.3969/j.issn.1671-8348.2011.28.007
充血性心力衰竭患者外周血中内皮素受体基因的表达及意义
Expression and significance of endothelin receptor of peripheral blood in patients with congestive heart failure
龚少愚 1周春刚 1高枫 1陆曙 1朱红俊1
作者信息
- 1. 南京中医药大学无锡附属医院/无锡市中医医院心内科,江苏无锡,214001
- 折叠
摘要
Abstract
Objective To study the expression and significance of endothelin receptor gene in patients with congestive heart fail ure (CHF) ,and to develop the method to measure gene endothelin receptor A (ETA) and endothelin receptor B(ETB) by retrovirus polymerase chain reaction(RT-PCR) in peripheral blood.Methods 48 CHF patients were enrolled,and 25 healthy volunteers were selected as the control group.Plasma endothelin (ET-1) was assessed by radioimmunoassay,and the expression of gene endothelin receptor was measured by RT-PCR.Results There was no statistically significant difference in ET-1 , ETA and ETB expression be tween NYHA ciass Ⅱ (13 case) and the control group.Alternatively,compared with the control group, the indices of ET-1 , ETA and ETB in NYHA class Ⅲ and NYHA class Ⅳ patients(35 case) were significantiy increased.Conclusion There is closely rela tionship between endothelin receptor gene and the occurrence and development of congestive heart failure.关键词
心力衰竭/受体,内皮素A/基因表达Key words
heart failure / receptor, endothelin A / gene expression引用本文复制引用
龚少愚,周春刚,高枫,陆曙,朱红俊..充血性心力衰竭患者外周血中内皮素受体基因的表达及意义[J].重庆医学,2011,40(28):2825-2826,2829,3.
