广东医学2011，Vol.32Issue(20)：2651-2654,4.
肝癌乙肝病毒感染患者术后预后的多因素分析
Prognosis of hepatocellular carcinoma patients with HBV infection after liver surgery: a multivariate analysis
摘要
Abstract
Objective To evaluate the prognostic factors of hepatocelluar carcmoma patients with HBV infection for liver surgery. Methods The clinical data of 211 HCC patients with HBV infection, who had received liver surgery,were retrospectively analyzed. Multivariate and univariate Cox proportional hazards models were used to investigate the correlations between clinical factors and survival. Kaplan - Meier method was used to plot the curves of accumulative survival rates and Log - rank test was used to test the P value. Results In univariate analysis using a Cox model, scores of TNM staging, treatments, portal vein tumor thrombus, size of tumor, alpha - fetoprotein ( AFP ) , gamma - glutamyl transpeptidase, aspartate aminotransferase, onset symptoms and antiviral therapy were significantly correlated with the prognosis for liver surgery ( P ＜ 0. 05 ). Gamma - glutamyl transpeptidase, aspartate aminotransferase, onset symptoms and antiviral therapy were revealed as independent factors of prognosis in multivariate Cox model analysis ( P ＜ 0. 05 ). Conclusion Gamma - glutamyl transpeptidase , aspartate aminotransferase , onset symptoms and antiviral therapy are independent prognostic factors of HCC patients with HBV infection for liver surgery. Active antiviral therapy is necessary for patients with HBV infection.关键词
乙肝病毒感染/肝癌/手术/预后Key words
HBV infection/ hepatocellular carcinoma/ surgery/ prognosis引用本文复制引用
曾钦,董忠谊,邹金金,罗何三,梁基韵,曹传辉,吴德华..肝癌乙肝病毒感染患者术后预后的多因素分析[J].广东医学,2011,32(20):2651-2654,4.基金项目
广东省自然科学基金资助项目(编号:10151051501000062) （编号:10151051501000062）
