山西医科大学学报2011，Vol.42Issue(10)：784-786,3.DOI:10.3969/j.issn.1007-6611.2011.10.003
HBsAg阳性母亲的婴儿乙肝疫苗免疫效果观察
Observation on immune effect of hepatitis B vaccine in infants born to HBsAg positive mothers
丰淑英1
作者信息
- 1. 太原市第三人民医院妇产科,太原,030012
- 折叠
摘要
Abstract
Objective To investigate the immune effect of different dosages of hepatitis B( HB ) vaccine in infants born to HBsAg positive mothers. Methods A total of 118 infants born to HBsAg positive mothers were divided into two groups,and were immunized with recombinant yeast-derived hepatitis B vaccines( 10 μg )or recombinant CHO cell derived hepatitis B vaccines( 20 g ), respectively. The HBsAg and anti-HBs were detected. The blocking effects of different doses of vaccine on mother-to-infant transmission of hepatitis B virus were compared. Results When the infants were born,HBsAg positive rate were 8.47％ and 5.08％ in 10 μg group and 20 μg group, respectively, and there was no significant difference between 2 groups. When the infants were 12 months old, HBsAg and antiHBs positive rates were not statistically significant between 2 groups, but the non( low )-responsive rate in 10 μg group was significantly higher than that in 20 μg group( P ＜ 0.05 ). Conclusion The immune effect of 20 μg vaccine is better than that of 10 μg vaccine for the infants born to HBsAg positive mothers.关键词
HBsAg阳性母亲/婴儿/乙肝疫苗/免疫效果Key words
HBsAg positive mother/ infant/ hepatitis B vaccine/ immune effect分类
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丰淑英..HBsAg阳性母亲的婴儿乙肝疫苗免疫效果观察[J].山西医科大学学报,2011,42(10):784-786,3.
