山西医科大学学报2011，Vol.42Issue(10)：818-821,859,5.DOI:10.3969/j.issn.1007-6611.2011.10.011
p21ras、p73在子宫内膜腺癌中的表达及意义
Expression of p21ras and p73 in endometrioid adenocarcinoma and its clinical significance
陈雪 1李美蓉1
作者信息
- 1. 山西医科大学第一临床医学院妇科,太原,030001
- 折叠
摘要
Abstract
Objective To investigate the expression of p2lras and p73 in endometrioid adenocarcinoma and its clinical significance.Methds Immunohistochemistry was applied to detect the expression of p2lras and p73 protein in 15 cases of normal proliferating endometrial tissues, 19 cases of atypical hyperplasia and 61 cases of endometrioid adenocarcinoma. Results The positive rates of p21ras and p73 gradually increased from normal proliferating endometrial tissues to endometrioid adenocarcinoma. There was a positive correlation between p73 and p2lras in endometrioid adenocarcinoma ( P ＜ 0. 01 ). Expression of p2lras and p73 was associated with the histological grade( P ＜ 0. 05 ) .but not related with clinical stage, myometrial invasion and lymph node metastasis. Conclusion The results suggest that the activation of p2lras and p73 may be correlated with the genesis and development of endometrioid adenocarcinoma. The combined detection of p2lras and p73 may provide a reference for early screening of high-risk subjects,pathological diagnosis of endometrioid adenocarcinoma.关键词
p21ras/p73/子宫内膜腺癌/免疫组织化学Key words
p21 ras / p73 / endometrioid adenocarcmoma / immunohistochemistry分类
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陈雪,李美蓉..p21ras、p73在子宫内膜腺癌中的表达及意义[J].山西医科大学学报,2011,42(10):818-821,859,5.
