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昆布多糖对家兔血小板聚集和释放的影响

曾惠芬 徐露

中国药业2011,Vol.20Issue(19):7-8,2.
中国药业2011,Vol.20Issue(19):7-8,2.

昆布多糖对家兔血小板聚集和释放的影响

Effect of Thallus Laminariae Polysaccharides on Platelet Aggregation and Release Reaction in Rabbits

曾惠芬 1徐露2

作者信息

  • 1. 南方医科大学附属小榄医院,广东,中山,528415
  • 2. 重庆医科大学药学院·重庆市生化与分子药理重点实验室,重庆,400016
  • 折叠

摘要

Abstract

Objective To investigate the effect of thallus laminariae polysaccharides(TLP) on platelet aggregation and release reaction in rabbits. Methods We observed the effect of TLP on platelet aggregation which was induced by PAF in rabbits in vivo study, using turbidimetry, and determined GMP- 140 in plasma using double antibody sandwich method. Results Compared with the saline group,TLP inhibited PAF-induced platelet aggregation were significantly different(P<0.05, P<0.01),and can reduce the content of GMP- 140( P <0.01 ). Conclusion TLP could resistant PAF-induced platelet aggregation and release,

关键词

昆布多糖/抗血小板聚集/二磷酸腺苷/血小板颗粒膜蛋白

Key words

TLP/ anti - platelet aggregation/ ADP/ GMP - 140

分类

医药卫生

引用本文复制引用

曾惠芬,徐露..昆布多糖对家兔血小板聚集和释放的影响[J].中国药业,2011,20(19):7-8,2.

基金项目

广东省中山市医学科学技术研究基镏金,项目编号:2010102. ()

中国药业

OACSTPCD

1006-4931

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