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Brain-derived neurotrophic factor gene transfection promotes neuronal repair and neurite regeneration after diffuse axonal injury

Yin Yu Chao Du Xingli Zhao Jiajia Shao Qiang Shen Tao Jiang Wei Wu Dong Zhu Yu Tian Yongchuan Guo

中国神经再生研究（英文版）2011，Vol.6Issue(25)：1942-1946,5.

中国神经再生研究（英文版）2011，Vol.6Issue(25)：1942-1946,5.DOI:10.3969/j.issn.1673-5374.2011.25.004

Brain-derived neurotrophic factor gene transfection promotes neuronal repair and neurite regeneration after diffuse axonal injury

Yin Yu ¹Chao Du ¹Xingli Zhao ¹Jiajia Shao ²Qiang Shen ³Tao Jiang ¹Wei Wu ⁴Dong Zhu ⁴Yu Tian ¹Yongchuan Guo¹

作者信息

1. Second Department of Neurosurgery, Bethune Third Hospital, China-Japan Friendship Hospital, Jilin University, Changchun 130031, Jilin Province, China
2. Changchun Vocational Institute of Technology, Changchun 130031, Jilin Province, China
3. Department of Neurosurgery, Jilin Provincial People's Hospital, Changchun 130000, Jilin Province, China
4. Department of Neurosurgery, Bethune First Hospital, Jilin University, Changchun 130021, Jilin Province, China
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摘要

Abstract

This study sought to assess the potential of brain-derived neurotrophic factor (BDNF) to promote neuronal repair and regeneration in rats with diffuse axonal injury, and to examine the accompanying neurobiological changes. BDNF gene transfection reduced the severity of the pathological changes associated with diffuse axonal injury in cortical neurons of the frontal lobe and increased neurofilament protein expression. These findings demonstrate that BDNF can effectively promote neuronal repair and neurite regeneration after diffuse axonal injury.

关键词

diffuse axonal injury/brain-derived neurotrophic factor/neurite/gene transfection/neural regeneration

Key words

diffuse axonal injury/brain-derived neurotrophic factor/neurite/gene transfection/neural regeneration

引用本文复制引用

Yin Yu,Chao Du,Xingli Zhao,Jiajia Shao,Qiang Shen,Tao Jiang,Wei Wu,Dong Zhu,Yu Tian,Yongchuan Guo..Brain-derived neurotrophic factor gene transfection promotes neuronal repair and neurite regeneration after diffuse axonal injury[J].中国神经再生研究（英文版）,2011,6(25):1942-1946,5.

基金项目

the National Natural Science Foundation of China (Key Program and General Program),No.10832012* （Key Program and General Program）

10872078* （）

中国神经再生研究（英文版）

OACSCD

ISSN：1673-5374

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