中国神经再生研究（英文版）2011，Vol.6Issue(25)：1977-1981,5.DOI:10.3969/j.issn.1673-5374.2011.25.010
Renovascular hypertension causes cerebral vascular remodeling
Renovascular hypertension causes cerebral vascular remodeling
摘要
Abstract
Renovascular hypertensive rats (RHRs) were developed using the 2-kidney, 2-clip method. All RHRs at 10 weeks displayed high permeability of the cerebral surface blood vessels. Vascular casts of the RHRs showed that the vascular network was sparse. The arterioles of the RHRs at 10 weeks had smaller lumen diameters, but thicker vessel walls with hyalinosis formation compared with control animals. The endothelial cell membrane appeared damaged, and microthrombus formed. After ischemia, the infarction size was larger in RHRs than in control animals. These results suggest that cerebral arterioles in RHRs underwent structural remodeling. High blood pressure may aggravate the severity of brain injury in cerebral ischemia and affect the recovery of ischemia.关键词
cerebral infarction/hypertension/renovascular hypertension/vascular structural remodeling/collateral circulationKey words
cerebral infarction/hypertension/renovascular hypertension/vascular structural remodeling/collateral circulation引用本文复制引用
Yamei Tang,Xiangpen Li,Yi Li,Qingyu Shen,Xiaoming Rong,Ruxun Huang,Ying Peng..Renovascular hypertension causes cerebral vascular remodeling[J].中国神经再生研究（英文版）,2011,6(25):1977-1981,5.基金项目
the Natural Science Foundation of Guangdong Province,No.10151130001000001*,S2011010004708* （）
and the Science and Technology Projects of Guangdong Province,No.2010Y1-C191* （）
