中国病理生理杂志2011，Vol.27Issue(10)：1977-1981,5.DOI:10.3969/j.issn.1000-4718.2011.10.023
痛风患者CXCL16血清水平的变化及临床意义
Change of serum CXC chemokine ligand 16 in gout patients and its clinical significance
摘要
Abstract
AIM: To explore the relationship between the changes of serum CXC chemokine ligand 16 ( CXCL16 ) and the loss of kidney functions in chronic gout patients and its clinical significance. METHODS: Twenty gout patients with chronic kidney disease ( CKD ), 22 gout patients without CKD and 22 CKD subjects were recruited into the present study, while 20 normal age - and sex - matched subjects were assigned into the control group. Serum level of CX-CL16 and other relevant clinical and biochemical parameters in all subjects were obtained upon standard clinical examinations. Ceatinine clearance rate ( CCR ) and estimated glomerular filtration rate ( eGFR ) were calculated based on the clinical parameters. To analyze the clinical data, student's unpaired t - test was used for the comparison between 2 groups. One - way ANOVA assay and multiple stepwise regression were used for multiple groups. RESULTS: Serum level of CXCL16 was significantly increased in gout subjects compared with the healthy control and CKD subjects ( P <0. 05 ). Serum level of CXCL16 in gout patients with CKD was significantly higher than that in gout patients without CKD ( P <0. 05 ). Furthermore, the mRNA expression of CXCL16 in peripheral blood mononuclear cells ( PBMC ) of gout patients was significantly higher than that in healthy subjects. Multiple stepwise regression analysis indicated that serum CXCL16 was independently associated with 24 h urine protein, CCR and C -reactive protein ( P <0. 05 ). CONCLUSION: Serum CXCL16 level in gout patients is associated with the change of renal functions. Elucidating the pathophysiologcial mechanism of CXCL16 in gout patients requires further study.关键词
CXC趋化因子配体16/痛风/肾脏功能Key words
CXC chemokine ligand 16/Gout/Renal function分类
医药卫生引用本文复制引用
吴帆,龚琦,俞佳文,卢婷婷,李校堃,林灼锋..痛风患者CXCL16血清水平的变化及临床意义[J].中国病理生理杂志,2011,27(10):1977-1981,5.基金项目
浙江省2010年温州市科技计划项目(No.H20100026) （No.H20100026）
