中国全科医学2011，Vol.14Issue(29)：3358-3361,4.
新疆维吾尔族弥漫大B细胞淋巴瘤的临床特征及预后影响因素分析
Clinical Characteristics and Prognostic Factors of Diffuse Large B-Cell Lymphoma among the Uygur Population in Xinjiang
贾存东 1梁莉萍 2闻淑娟 1古力克孜·吾守尔 1赵兵 1刘炜 1白靖平 3杨顺娥1
作者信息
- 1. 830011新疆乌鲁木齐市,新疆医科大学附属肿瘤医院内三科
- 2. 830011新疆乌鲁木齐市,新疆医科大学附属肿瘤医院病理科
- 3. 830011新疆乌鲁木齐市,新疆医科大学附属肿瘤医院骨与软组织肿瘤科
- 折叠
摘要
Abstract
Objective To investigate the clinical characteristics and prognostic factors of Uygur patients with diffuse large B - cell lymphoma ( DLBCL ). Methods Clinical data of 134 Uygur Patients with DLBCL treated by our hospital from Jan. 2000 to Dec. 2009 were retrospectively analyzed. Kaplan - Meier method was used for survival analysis and Cox regression model was applied for multivariate analysis. Results Median age of the whole studied group was 38 years ( ranged from 13 to 73). Of the 134 patients, 85 were men, and 49 were women. According to Ann Arbor stage classification, 93 (69.4%) patients were defined as stage IH or ]V ; 50 patients ( 37. 3% ) were grouped as middle - risk and high - risk according to their international prognostic index ( IPI ). Before treatment, 42 ( 31. 3% ) patients displayed anemia, 47 ( 35. 1% ) were with bulk, 50 ( 37. 3% ) presented B symptoms, and 92 ( 68.7% ) showed performance status ( PS ) scores ( designed by Eastern Cooperative Oncology Group [ ECOG ] ) of 0 ~ 1. The median overall survival time was 37 months [ 95% CI ( 24. 9, 49. 1 ) ]. Three - year and 5 - year overall survival ( OS ) rates were 51% and 35% respectively. Univariate analysis showed that age, Ann Arbor stage, non - lymph node lesions, ECOG PS, lactic dehydrogenase ( LDH ), IPI, and bone marrow involvement were correlated to the prognosis among Uygur population significantly ( P < 0. 01 ). Multivariate analysis showed that Ann Arbor stage, ECOG PS and LDH level were independent prognostic factors ( P <0. 05 ). Conclusion Overall survival rate of Uygur patients with DLBCL is low. Ann Arbor stage, PS and LDH level might serve as reference for prediction of the prognosis of Uygur patients with DLBCL.关键词
淋巴瘤,大B细胞,弥漫性/维吾尔族/临床特征/预后/存活率Key words
Lymphoma, large B - cell, diffuse/ Uygur nationality/ Clinical features/ Prognosis/ Survival rate分类
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贾存东,梁莉萍,闻淑娟,古力克孜·吾守尔,赵兵,刘炜,白靖平,杨顺娥..新疆维吾尔族弥漫大B细胞淋巴瘤的临床特征及预后影响因素分析[J].中国全科医学,2011,14(29):3358-3361,4.
