中国组织工程研究与临床康复2011，Vol.15Issue(39)：7392-7395,4.DOI:10.3969/j.issn.1673-8225.2011.39.043
甲强龙预防下肢长骨骨折后脂肪栓塞综合征作用的Meta分析
Effect of methylprednisolone on the prevention of fat embolism syndrome after diaphyseal fractures of the lower limb: A Meta-analysis
赵志刚 1贾新华 2勘武生 1李鹏1
作者信息
- 1. 武汉市普爱医院,武汉市骨科医院骨三科,湖北省武汉市,430033
- 2. 汉川市第二人民医院骨科,湖北省汉川市,431602
- 折叠
摘要
Abstract
BACKGROUND: Fatembolism syndorome is common in patients with diaphyseaI fractures of the lower limb. Corticosteroids arethe main preventive and treatment method. However, there are different results in various relevant studies.OBJECTIVE: To analyze the effect of methylprednisolone on the prevention of fat embolism syndrome after diaphyse alfracturesof the lower limb.METHODS: By searching Medline, EMBSE. CENTRAL, C8M.CNKI and Wanfang databases, we collected both domestic andoverseas published randomized controlled trials about the effect of methylprednisolone on the prevention of fat embolismsyndrome after diaphyseal fractures of the lower limb. The outcome was measured by relative risk (RR) and its 95% confidenceinterval (C/).RESULTS AND CONCLUSION: Six trials that included a total of 410 patients were analyzed in the systematic review. 184patients were in the methylprednisolone group and 205 patents were in the placebo group. The pooled relative risk for developingfat embolism syndrome was 0.20 (95%C/0.09-0.43, 2=4.07, P=0.000) in the methylprednisolone group as compared with thecontrol group. The methylprednisolone decreased the risk of developing fat embolism syndrome after diaphyse al fractures of thelower limb.关键词
下肢长骨骨折/甲强龙/脂肪栓塞综合征/安慰剂/Meta/分析分类
医药卫生引用本文复制引用
赵志刚,贾新华,勘武生,李鹏..甲强龙预防下肢长骨骨折后脂肪栓塞综合征作用的Meta分析[J].中国组织工程研究与临床康复,2011,15(39):7392-7395,4.
