中国组织工程研究与临床康复2011，Vol.15Issue(32)：5987-5990,4.DOI:10.3969/j.issn.1673-8225.2011.32.022
脐带间充质干细胞移植治疗终末期肝硬化的疗效及安全性
Effect and safety of umbilical cord mesenchymal stem cells transplantation on end-stage liver cirrhosis
周炳喜 1郭俊贤 1韩双印 1张延瑞1
作者信息
- 1. 河南省人民医院消化内科,河南省郑州市,450003
- 折叠
摘要
Abstract
BACKGROUND: Bone mesenchymal stem cells (BMSCs) transplantation has been used for end-stage liver cirrhosis, and obtained some results. OBJECTIVE: To observe the effect and safety of umbilical cord mesenchymal stem cells (UCMSCs) transplantation on end-stage hepatic cirrhosis. METHODS: UCMSCs were isolated under sterile conditions. Sixty cases of liver cirrhosis received basic medication and UCMSCs transplantation by way of hepatic artery. RESULTS AND CONCLUSION: After UCMSCs treatment, the level of albumin, prealbumin and fibrinogen were significantly increased (P ＜ 0.05), and the levels of total bilirubin and prothrombin time were obviously reduced (P ＜ 0.05). The symptoms such as fatigue, abdominal distension, anorexia relieved after treatment. UCMSCs transplantation for end-stage liver cirrhosis is safe and effective, and it can improve patients' liver function, blood clotting and relieve clinical symptoms.关键词
肝硬化/脐带间充质干细胞/终末期/疗效/安全性分类
医药卫生引用本文复制引用
周炳喜,郭俊贤,韩双印,张延瑞..脐带间充质干细胞移植治疗终末期肝硬化的疗效及安全性[J].中国组织工程研究与临床康复,2011,15(32):5987-5990,4.
