中国全科医学2011，Vol.14Issue(29)：3322-3324,3.
吸烟对结直肠癌发生发展的影响研究
Impact of Smoking on Pathogenesis and Development of Colorectal Neoplasms
摘要
Abstract
Objective To explore the impact of smoking on the development of colorectal neoplasms. Methods A total of 119 male colorectal neoplasm patients underwent operation and pathologic diagnosis in recent years in our hospital were enrolled. These patients were divided into the smoking group ( 63 cases ) and the non - smoking group ( 56 cases ) before operation and further divided into the keep - smoking group ( 39 cases ), the quit - smoking group ( 24 cases ) and the non - smoking group ( 56 cases ) after operation. Results Preoperative carcinoembryonic antigen ( CEA ) and C reactive protein ( CRP ) values showed no statistically significant difference between the smoking group and the non - smoking group ( P > 0. 05 ) . Local recurrence rate, metastasis rate, and CEA values were significantly higher in the keep - smoking group than in the non - smoking group and the quit - smoking group ( P < 0. 05 ) . Survival rates of one year, two years, and three years were not significantly different among the three groups after operation ( P >0. 05 ) . Conclusion Smoking mainly affects CEA values before and after operation as well as local recurrence rate and metastasis rate during the pathogenesis and development of colorectal neoplasms.关键词
吸烟/结直肠肿瘤/癌胚抗原Key words
Smoking/ Colorectal neoplasms/ Carcinoembryonic antigen分类
医药卫生引用本文复制引用
张勰义,张晨鹏,孙晓光,黄钢..吸烟对结直肠癌发生发展的影响研究[J].中国全科医学,2011,14(29):3322-3324,3.基金项目
国家自然科学基金(81071180) （81071180）
上海市科委项目(10JC1410000) （10JC1410000）
