首页|期刊导航|中国神经再生研究（英文版）|Bilobalide inhibits the expression of aquaporin 1, 4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia
中国神经再生研究（英文版）2011，Vol.6Issue(27)：2105-2111,7.DOI:10.3969/j.issn.1673-5374.2011.27.004
Bilobalide inhibits the expression of aquaporin 1, 4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia
Bilobalide inhibits the expression of aquaporin 1, 4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia
摘要
Abstract
The present results demonstrated that in an adult rat model of permanent middle cerebral artery occlusion (pMCAO), pretreatment with bilobalide reduced brain water content and infarct area, down-regulated aquaporin 1, 4 mRNA expression in brain edema tissue, then inhibited their synthesis in the striatum, in particular at the early stage of ischemia (at 8 hours after pMCAO), inhibited glial fibrillary acidic protein expression, and lightened reactive gliosis. These data sug-gest that bilobalide attenuates brain edema formation due to reduced expression of aquaporins.关键词
bilobalide/aquaporin/brain edema/permanent middle cerebral artery occlusion/glial fibrillary acidic protein/neural regenerationKey words
bilobalide/aquaporin/brain edema/permanent middle cerebral artery occlusion/glial fibrillary acidic protein/neural regeneration引用本文复制引用
Haiming Qin,Fulin Song,Hongguang Han,Hong Qu,Xingwen Zhai,Bin Qin,Song You..Bilobalide inhibits the expression of aquaporin 1, 4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia[J].中国神经再生研究（英文版）,2011,6(27):2105-2111,7.基金项目
a Research Subject of General Hospital of Shenyang Military Area Command of Chinese PLA （）
