中国病理生理杂志2011，Vol.27Issue(10)：2030-2034,5.DOI:10.3969/j.issn.1000-4718.2011.10.035
糖皮质激素对脑内炎症反应的促进作用
Pro-inflammatory effect of glucocorticoids in brain
摘要
Abstract
Glucocorticoids are necessary for stress response and universally used as anti - inflammatory agents. However, recent studies indicate that glucocorticoids not only enhance the pro - inflammatory effect of stress in the brain but also aggravate brain inflammation when glucocorticoid level is chronically elevated or abnormally increased. In addition, inflammatory response has detrimental effects on the repair of injury in the brain and contributes to several neuropsychiatric diseases. Accordingly, the capacity of glucocorticoids to augment inflammation in the brain deserves further investigation for effective clinical attenuation of brain inflammation. In this paper, we review recent advances in the characteristics and the possible mechanisms of the pro - inflammatory effect of glucocorticoids in the brain.关键词
糖皮质激素类/脑/炎症/应激Key words
Glucocorticoids/Brain/Inflammation/Stress分类
医药卫生引用本文复制引用
顾云,庄重..糖皮质激素对脑内炎症反应的促进作用[J].中国病理生理杂志,2011,27(10):2030-2034,5.基金项目
江苏省"青蓝工程"资助项目 （）
