反相高效液相色谱法测定布南色林原料的含量及有关物质OACSTPCD
Determination of the Content of Blonanserin and Its Related Substances by RP-HPLC
目的 建立测定布南色林及其有关物质含量的反相高效液相色谱法.方法 色谱柱为Waters Xterra RP18柱(250 mm×4.6mm,5μm),流动相为乙腈-甲醇-25 mmol/L的磷酸二氢钠溶液(内含25mmol/L庚烷磺酸钠,用磷酸调pH至3.0,35∶30∶35),检测波长为243 nm,流速为1 mL/min,柱温为30℃,进样量为10μL.结果 布南色林检测质量浓度的线性范围为1.022～10.22μg/mL(r=0.999 4…查看全部>>
Objective To establish an RP - HPLC method for the determination of blonanserin and its related substances. Methods Tie method was performed on a Waters Xterra RP18 column(250 mm ×4. 6 mm,5 μm) using acetonitrile - methanol - 25 mmol NaH2PO4 (containing 25 mmol sodium 1 -heptanesul - fonate,pH =3. 0 adjusted by phosphate acid,35 ∶ 30 ∶ 35) as the mobile phase at a flow rate of 1 mL/min. The detection wavelength was at 243 nm. The column temperat…查看全部>>
廖华卫;陈云;白家和
广东省雷州市人民医院,广东,湛江,524200广东省雷州市人民医院,广东,湛江,524200广东省雷州市人民医院,广东,湛江,524200
医药卫生
高效液相色谱法布南色林含量测定有关物质
HPLC blonanserin content determination related substances
《中国药业》 2011 (19)
30-31,2
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