首页|期刊导航|中华医学杂志（英文版）|Clinical effects of autologous stem cell transplantation as consolidation treatment in 70 multiple myeloma patients:a case-controlled study
中华医学杂志（英文版）2011，Vol.125Issue(19)：2975-2980,6.DOI:10.3760/cma.j.issn.0366-6999.2011.19.003
Clinical effects of autologous stem cell transplantation as consolidation treatment in 70 multiple myeloma patients:a case-controlled study
Clinical effects of autologous stem cell transplantation as consolidation treatment in 70 multiple myeloma patients:a case-controlled study
摘要
Abstract
Background Autologous stem cell transplantation (ASCT) is a part of the standard induction therapy of multiple myeloma (MM). This case-controlled clinical trial aimed to further evaluate the therapeutic effects of ASCT as a consolidation therapy for MM and discuss factors influencing the prognosis.Methods Clinical data of 70 patients diagnosed as MM who received ASCT as a consolidation therapy in our hospital between October 1998 and August 2010 were analyzed retrospectively (ASCT group). Other 70 MM patients receiving routine chemotherapy without ASCT (non-ASCT group) during the same period were used as controls. Differences in the degree and duration of remission, progression-free survival (PFS) and overall survival (OS) were compared to explore factors that may influence the prognosis.Results The median follow-up period was 38 months (range 1-128 months). The complete response (CR) rate of ASCT group increased from 27.1％ (19/70) before ASCT to 51.4％ (36/70) after ASCT. The median PFS of ASCT group was significantly higher than non-ASCT group (45 months vs. 25 months, P ＜0.001). The median OS of ASCT group was also significantly higher (55 months vs. 30 months, P=0.016). Single-factor analysis showed that International Staging System (ISS) stage, very good partial response (VGPR) or better outcome were significantly correlated with PFS and OS (P ＜0.001). Multi-factor analysis showed that whether or not VGPR or better outcome was achieved were independent factors influencing the disease prognosis.Conclusion Used as a consolidation therapy, ASCT can achieve better responses and higher OS and PFS of MM patients.关键词
hematopoietic stem cell transplantation/multiple myeloma/prognosis/survivalKey words
hematopoietic stem cell transplantation/multiple myeloma/prognosis/survival引用本文复制引用
ZHOU Li-li,HOU Jian,YUAN Zhen-gang,FU Wei-jun,XI Hao,ZHANG Chun-yang,LAN Hai-feng,ZHANG Xin,CHEN Yu,LIU Wen-yu..Clinical effects of autologous stem cell transplantation as consolidation treatment in 70 multiple myeloma patients:a case-controlled study[J].中华医学杂志（英文版）,2011,125(19):2975-2980,6.基金项目
The study was partly supported by the National Natural Science Foundation of China (No.81001050) and the Health Ministry Foundation for Clinical Sciences Development (Project 2010-2012). （No.81001050）
