重庆医学2011，Vol.40Issue(31)：3138-3139,3142,3.DOI:10.3969/j.issn.1671-8348.2011.31.007
曲格列酮对人胃癌细胞株BGC-823增殖和凋亡的影响
Effects of troglitazone on proliferation and apoptosis of BGC-823 cells
王静 1王春晖2
作者信息
- 1. 成都医学院第一附属医院消化内科,成都,610500
- 2. 四川大学华西医院消化内科,成都,610041
- 折叠
摘要
Abstract
Objective To investigate the effects of troglitazone on proliferation and apoptosis in gastric cancer cell line BGC-823. Methods BGC-823 cells were treated with different concentrations(0. 5 ,1. 0 , 5. 0 ,15. 0 and 25. 0 μmol/L)of troglitazone for 48 h, then the expression of proliferating cell nuclear antigen (PCNA) on the cells were detected by immunocytochemistry and the induction of apoptosis were investigated by TUNEL assay. Results The expression of PCNA could be observed in BGC-823 and down-regulated by troglitazone at the end of 48 h. The level of PCNA was gradually become weakened on the concentration range from 0. 5 μmol/L to 25. 0 μmol/L. At the same time,the apoptosis indexes of BGC-823 were significantly increased. Conclusion Troglitazone can inhibit the proliferation and induce apoptosis of the gastric cancer cell line BGC-823 in a dose dependent manner.关键词
胃肿瘤/增殖/凋亡/曲格列酮Key words
stomach neophasms/ proliferation/ apoptosis/ troglitazone引用本文复制引用
王静,王春晖..曲格列酮对人胃癌细胞株BGC-823增殖和凋亡的影响[J].重庆医学,2011,40(31):3138-3139,3142,3.
