国际医药卫生导报2011，Vol.17Issue(17)：2086-2089,4.DOI:10.3760/cma.j.issn.1007-1245.2011.17.004
流式细胞技术检测非小细胞肺癌肋骨骨髓微转移
Flow cytometric detection of micrometastases to rib marrow in patients with non-small lung cancer
摘要
Abstract
Objective To evaluate the detection value of rib bone marrow micrometastasis ( BMM ) in patients with non-small lung cancer ( NSCLC ) by using flow cytometry ( FCM ) and determine the relationship between BMM and clinicopathological parameters. Methods 158 patients undergoing surgical treatment for NSCLC during April 2004 to May 2007 were prospectively analyzed. Bone marrow aspirates were obtained intraoperatively and the expression rate of the postive cells was determined by using flow cytometry. Results 59of the 158 ( 37.34 ％ ) patients occurred, 18 ( 30.51％ ) of whom developed distant metastases. 14 of the 99 ( 13.9％ ) patients without BMM developed distant metastases.BMM was correlated with tumor size and tumor stage, but not with age, sex, pathological types, differentiation degrees. The bigger the tumor size and the higher the tumor stage, the higher the frequency of BMM.Patients with BMM had a higher metastatic rate than in those without BMM ( P ＜ 0.05 ). Conclusions Non-small lung cancer can occur early bone marrow micrometastasis. BMM is correlated with some clinic pathological parameters. Detection of BMM by flow cytometry can be used as an indicator for instruction of treatment and prediction of prognosis.关键词
流式细胞术；非小细胞肺癌；骨髓微转移Key words
Flow cytometry/Non-small lung cancer/Bone marrow micrometastasis引用本文复制引用
卢珠明,伍硕允,李秀娟,叶敏,林志潮,黄文海,庞文广,庞景灼..流式细胞技术检测非小细胞肺癌肋骨骨髓微转移[J].国际医药卫生导报,2011,17(17):2086-2089,4.基金项目
广东省江门市科学技术立项课题(2008-4036) （2008-4036）
