摘要
Abstract
Objectives To explore the clinical significance of detection of HBV Pre-S1 antigen in the diagnosis of Hepatitis B. Methods 254 blood samples with positive HBV markers detected by ELISA were divided into three groups based on different modes. Pre-S 1 antigen, HBV DNA, and ALT were detected in each group and then were comparatively analyzed. Results The detection rates for PreS1 antigen and HBV-DNA were 77.5％ and 93.1％ in the group with HbsAg ( + ), HBeAg ( + ), and HBcAb ( + ), 45.7％ and 60.1％ in the group with HBsAg ( + ), HBeAb ( + ), and HBcAb ( + ); and 0％ and 14.3％ in the group with HBsAg (-), HBeAb ( + ), and HBcAb ( + ). The positive rate of PreSl was 64.4％ ( 116/180 ) and A LT abnormality rate was 61.1％ ( 110/180 ) in 180 samples with a HBVDNA copy number of greater than 500IU/ml, and they were 35.1％ and 33.8％ in 74 samples with a copy number of less than 500IU/ml, respectively. The positive of Pre-S1 antigen was increased with an elevation in HBV DNA viral load, but the ALT abnormality rate was not linearly associated with the increase in HBV DNA viral load. Conclusions HBV Pre-Sl antigen has a higher consistency with HBV-DNA, which has an important clinical value in the diagnosis of type B hepatitis and can provide more reliable referrence for judging viral replication in vivo and efficacy of treatment.关键词
乙型肝炎病毒；乙肝病毒前Sl抗原；HBV-DNA载量；丙氨酸氨基转移酶(ALT)Key words
Hepatitis B virus/Pre-Sl antigen/HBV DNA viral load/ALT
