中医药学报2011，Vol.39Issue(3)：30-32,3.
PAMD对MCAO局灶性脑缺血模型大鼠脑皮质NF-κBp65蛋白表达的影响
The Effect of PAMD on Protein Expression of Pallium NF- κBp65 of Model Rats with MCAO Focal Cerebral Ischemia
摘要
Abstract
Objective: To study and explore the neuroprotective effects and the further mechanism of Phenolie Alkaloids-from MenisPermum Daurieum on cerebral ischemia in rats. Methods; In order to observe the neuroprotective effect of Phenolie Alkaloidsfrom MenisPermum Daurieum on cerebral ischemia, the rats with incomplete cerebral ischemia were induced with fishing lines in the middle cerebral artery ( MCA) and then were executed after cerebral ischemia. It was detected the effects of Phenolie Alkaloidsfrom MenisPermum Daurieum on protein expression of NF - κBd65 with immu-neohistochemical method. Results: PAMD could inhibit the expression of NF - κBp65 protein of model rats. Conclusion: Phenolie Alkaloidsfrom MenisPermum Daurieum has a protective effect on cerebral ischemia and the mechanism of Phenolie Alkaloidsfrom MenisPermum Daurieum against cerebral ischemia is related to inhibiting anti - inflammatory action and affecting the related expression of NF - κBp65 protein interrelated with anti - inflammatory action.关键词
蝙蝠葛酚性碱；脑缺血；抗炎作用；NF-κBp65Key words
Phenolie Alkaloidsfrom MenisPermum Daurieum/Cerebral Ischemia/Anti - inflammatory Action/Nuclear Factor Kappa Bp65 (NF - κBp65)分类
医药卫生引用本文复制引用
赵鑫,白云,周忠光,苏慧,苏云明..PAMD对MCAO局灶性脑缺血模型大鼠脑皮质NF-κBp65蛋白表达的影响[J].中医药学报,2011,39(3):30-32,3.基金项目
哈尔滨市优秀学科带头人项目(编号：2007RFXXS060)；黑龙江省科技攻关计划项目(编号：GC05C31403)；黑龙江省中医管理局项目(编号：ZHY08-W11) （编号：2007RFXXS060）
