首页|期刊导航|中华医学杂志（英文版）|Increased plasma C-reactive protein level predicts rapid progression of non-target atherosclerotic lesions in patients with stable angina after stenting
Increased plasma C-reactive protein level predicts rapid progression of non-target atherosclerotic lesions in patients with stable angina after stenting
XU Yan-lu MA Wei-hua YAO Min LIU Hai-bo WU Yong-jian CHEN Jue YOU Shi-jie DAI Jun XIA Ran GAO Run-lin LI Jian-jun XU Bo ZHUCheng-gang YANG Yue-jin CHEN Ji-lin QIAO Shu-bing YUAN Jin-qing QIN Xue-wen
中华医学杂志（英文版）2011，Vol.125Issue(19)：3022-3029,8.
中华医学杂志（英文版）2011，Vol.125Issue(19)：3022-3029,8.DOI:10.3760/cma.j.issn.0366-6999.2011.19.013
Increased plasma C-reactive protein level predicts rapid progression of non-target atherosclerotic lesions in patients with stable angina after stenting
Increased plasma C-reactive protein level predicts rapid progression of non-target atherosclerotic lesions in patients with stable angina after stenting
摘要
Abstract
Background Although the role of C-reactive protein (CRP) in predicting rapid progression of atherosclerotic lesions has been intensively studied in unstable coronary artery disease, the data from patients with stable angina (SA) are largely absent. The present study evaluated a middle-size patient cohort who underwent percutaneous coronary intervention (PCI) with stent implantation and follow-up coronary angiography (CAG) and tested the hypothesis that increased plasma level of high-sensitive CRP would indicate rapid progression of de novo non-target coronary artery lesions in Chinese patients with SA.Methods The study population comprised of 311 consecutive patients with chronic SA who underwent coronary stent implantation on initial admission and angiographic follow-up ((8.5±1.2) months). Rapid angiographic progression of non-target lesion was angiographically assessed and the patients were classified into two groups according to whether the progression existed or not. The relation of plasma CRP levels to the progression of atherosclerosis was investigated.Results Baseline demographic, clinical, and angiographic data were similar in patients with and without progression.Rapid angiographic progression of non-target lesions occurred in 136 patients (43.7％) at follow-up: 77 had a ≥10％diameter reduction of pre-existing stenosis ≥50％, 26 had a ≥30％ diameter reduction of a pre-existing stenosis ＜50％, 64 developed a new lesion ≥30％ in a previously normal segment, and 4 had progression of a lesion to total occlusion.Progression of non-target lesions was not associated with target lesion restenosis formation. High-sensitive CRP levels were markedly higher in progression patients than in non-progression ones (1.60 (0.80-3.46) mg/L vs. 0.96 (0.55-1.87)mg/L, P ＜0.001). Multivariate regression analysis showed that plasma CRP independently predicted rapid angiographic progression of non-target lesions (P=0.001). High-sensitive CRP levels above 1.32 mg/L (the cutoff value) were associated with a 3.5-fold increase in the risk of developing rapid atherosclerotic progression (OR=3.497, 95％ CI 2.045-5.980).Conclusion The data confirmed and extended previous studies that plasma CRP might independently predict non-target lesion progression in patients with SA after stent implantation.关键词
C-reactive protein/inflammation/angina pectoris/angiography/stentsKey words
C-reactive protein/inflammation/angina pectoris/angiography/stents引用本文复制引用
XU Yan-lu,MA Wei-hua,YAO Min,LIU Hai-bo,WU Yong-jian,CHEN Jue,YOU Shi-jie,DAI Jun,XIA Ran,GAO Run-lin,LI Jian-jun,XU Bo,ZHUCheng-gang,YANG Yue-jin,CHEN Ji-lin,QIAO Shu-bing,YUAN Jin-qing,QIN Xue-wen..Increased plasma C-reactive protein level predicts rapid progression of non-target atherosclerotic lesions in patients with stable angina after stenting[J].中华医学杂志（英文版）,2011,125(19):3022-3029,8.基金项目
This study was partly supported by grants for PhD.candidate from Fu Wai Hospital (No.2004190),National Natural Science Foundation of China (No.30670861,No.30871055 and No.81070171),Beijing Natural Science Foundation (No.7082081),and Specialized Research Fund for the Doctoral Program of High Education of China (No.20070023047).Conflict of interest:None. （No.2004190）
